Medicube Zero Exosome Shot 7

Overview

Medicube markets this on collagen, and you use it as a targeted treatment step. With a strong 4.5 out of 5 from 5k ratings, it is a well-liked pick. It uses active ingredients, so patch test first and introduce it slowly if your skin is reactive.

The summary above follows how Medicube markets this product. We also read the published ingredient list line by line, and it tells a different story: what the ingredient order actually says.

At a glance

What buyers actually say

We read a sample of the Amazon reviews for this product and describe the pattern in our own words. It is a sample, not a survey of all 5,781 ratings, and we do not reproduce customer reviews.

Almost every reviewer in our sample leads with the sensation. The spicules produce a prickling or stinging feeling on application that people compare to needles, and most frame it as tolerable and a sign the product is doing something. After that, the consistent report is smoother texture and softer, more even-looking skin, sometimes within days, with several layering a collagen product or a rich moisturiser straight afterwards. Users of the weaker version who moved up describe the stronger one as noticeably more intense. The dissenting review is precisely about that intensity: one buyer found their face too sensitive to touch for a week.

How the ratings break down

Amazon's own star distribution for this product, read on 2026-09-30. We show the one-star share too, because an average alone hides it.

7% of these ratings are one or two stars. That is about typical for the Medicube range, where the median is 6%.

We cannot tell you what those reviewers said. Amazon.co.uk now requires an account to open the full review list, so the critical reviews are not readable from a public page. We would rather say that than guess.

What is exosomes?

Exosomes are cell-signaling particles used in skincare to support a more intensive, treatment-style boost to skin recovery and glow.

Ingredients, as listed by Medicube

Taken from Medicube's own product page on 2026-08-04. We have not verified it against a physical pack, and formulations change by market and batch. If an ingredient matters to you, check the pack itself.

Show the full ingredient list (26 ingredients)

Water, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Extracellular Lactobacillus Vesicle, Butylene Glycol, Niacinamide, Oenothera Biennis (Evening Primrose) Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Ulmus Davidiana Root Extract, Ethylhexyl Palmitate, Hydrolyzing. The sponge ium silicate, sodium silicate, sodium polyacrylate, hydrogenated polydecene, caprylyl/capryl glucoside, C12-14 Alketh-12, Campsis Grandiflora flower extract, ethylhexylglycerin, adenosine, disodium EDTA, panthenol, betaine salicylate, citric acid, gluconolactone.

What we can and cannot read from this list

• A caveat first: the only public ingredient list we have is Amazon's, and it is visibly garbled in the middle. One line reads "Hydrolyzing. The sponge ium silicate", clearly a mangled version of hydrolysed sponge and a silicate, so treat this list as incomplete and the positions below as approximate.
• What is solid: the exosome story is a lactobacillus ferment (extracellular vesicles) sitting fifth, and niacinamide sits seventh. The garbled sponge entry is the spicules, the microscopic needles the product is named for.
• Spicules are a physical mechanism, not a chemical one: thousands of tiny slivers that create micro-channels and a deliberate tingling, prickling feeling. That is the whole point of the product, and it is also exactly why it is not for everyone.

Our read

This is the range's most aggressive treatment: a physical spicule serum with a ferment-and-niacinamide backbone. Committed users use it as a weekly reset and accept the prickle. It is the single easiest product in the catalogue to buy by mistake, because nothing about the bottle says how physical the experience is.

Who should skip this

• Your skin is sensitive, reactive, or barrier-compromised. Physical spicules on a weakened barrier is a genuinely bad idea.
• You use a retinoid or exfoliating acids. Stacking spicules on top is a common route to a wrecked barrier.
• You expect a serum-like experience. This tingles and prickles by design; if that sounds unpleasant, believe your instinct.

A note on how we read that list. Ingredient lists run in descending order of concentration, but only for ingredients above 1%. Below that, the order is up to the manufacturer, so a low position tells you something is present at a low level, not exactly how much. We do not guess at percentages. FDA labeling guide.

Watch: medicube Zero Exosome Shot 7,500 PPM Spicule in action

What the listing says

Medicube's own description of this product, as published on its Amazon.co.uk listing. It is marketing copy, not our assessment, and we have not verified the claims in it.

• Viral product beloved by everyone - Transform your skin with the Exosome + Shot Booster. Featuring a micro-sized, needle-shaped design and enriched with 15M patented Exosome shots for precise treatment, this booster delivers active ingredients directly to your pores to tackle various skin issues.
• Exosome-Coated Technology - Harness the next-generation skincare with Exosome-coated Spicule and Exosome, penetrating deep into the skin to deliver active ingredients effectively. Our advanced formula is designed to address a range of skin concerns, from pore care to enhancing skin vitality and energy.
• Superior Absorption & Hydration - Achieve unmatched hydration and absorption rates with our formula, which enhances active ingredient uptake by 242% compared to standalone use. Ingredients like Niacinamide and Panthenol boost skin barrier and improve hydration levels, ensuring your skin remains supple and radiant.
• Clinically Proven & Gentle on Skin - Enjoy peace of mind with our clinically validated Tingling Ampoule that is non-comedogenic, tested to be low-irritating, gluten-free, and free from artificial colors. Suitable for all skin types, including sensitive skin.
• Easy to Integrate into Skincare Routine - Apply our Tingling Ampoule easily with a three-step routine, starting with a cleansing pad, followed by the Zero One Day Exosome Shot, and finish with a water-based moisturizer like Medicube’s Collagen Jelly Cream. For an added boost, use after the "Air Shot Mode" of the AGE-R Booster Pro to maximize effects.

Full listing title: Zero Exosome Shot 7,500 PPM Spicule Facial Serum | Liquid Skin Booster Serum | Exosome, AHA+BHA+PHA | Pore Care, Dead Skin Cells, Skin Texture | Korean Skin Care 30 | Liquid Skin Booster with Exosomes, AHA+BHA+PHA, Pore Care, Skin Skin Care, Exfoliating Care, Korean Skin Care, 30ml

Frequently asked questions

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